A case report of Apert syndrome with review of literatures

Apert syndrome is a rare which presents with craniosynostosis, severe syndactyly, and dysmorphic facial features. It mainly caused by new mutation in fibroblast growth factor receptor-2 gene. Up-regulation of this gene results bone fusion nuclear deficiency the transcription FoxO1 key pathogenesis acne. We present herein 19-year-old man nodulocystic acne associated acrocephaly, prominent forehead, ocular hypertelorism, short broad nose, high arched palate, maxillary hypoplasia, dental crowding ectopia, bilateral syndactyly hands feet. was diagnosed for him based on mentioned clinical findings. Isotretinoin 20 mg/day prescribed significant improvement two months later. Severe early puberty synostosis hallmark we should mindful these syndromic cases dermatology clinic.